Piperidine → 2,3,4-Tris(octadecyloxy)benzhydryl amine

HRID 573967노트

반응식

HRID 573967 반응식
C1C2C(COC([NH:18][CH:19]([C:83]3[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=3)[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])=[C:22]([O:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH3:63])[C:21]=3[O:64][CH2:65][CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][CH2:81][CH3:82])=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>C(Cl)(Cl)Cl.C(#N)C>[CH2:65]([O:64][C:21]1[C:22]([O:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][CH2:52][CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH3:63])=[C:23]([O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH:24]=[CH:25][C:20]=1[CH:19]([NH2:18])[C:83]1[CH:88]=[CH:87][CH:86]=[CH:85][CH:84]=1)[CH2:66][CH2:67][CH2:68][CH2:69][CH2:70][CH2:71][CH2:72][CH2:73][CH2:74][CH2:75][CH2:76][CH2:77][CH2:78][CH2:79][CH2:80][CH2:81][CH3:82]

참가 물질

5

반응물 2

HCID 8082PiperidineHCID 59510359N-Fmoc-[phenyl(2,3,4-trioctadecanoxyphenyl)methyl]amine

생성물 1

HCID 469361412,3,4-Tris(octadecyloxy)benzhydryl amine수율 98%

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 6342Acetonitrile용매

실험 절차

N-(9-Fluorenylmethoxycarbonyl)-2,3,4-tris(octadecyloxy)benzhydryl amine (3.37 g, 2.89 mmol) was dissolved in a mixed solvent of chloroform (30 mL) and acetonitrile (15 mL), 20% piperidine [1-methyl-2-pyrrolidone solution] (28.6 mL, 57.9 mmol) was added, and the mixture was stirred at room temperature for 30 min. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, methanol was added, and the precipitated solid was collected by filtration. The obtained solid was dried under reduced pressure to give the title compound (2.80 g, 97.9%) as a white solid.

후처리

  1. additionwas added
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure, methanol
  4. additionwas added
  5. filtrationthe precipitated solid was collected by filtration
  6. customThe obtained solid was dried under reduced pressure

출처 및 근거

ORD 기록
ord-f3fa4eab4f7f424d9c4f1615444d0221
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09029528B2

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