Hydrochloric Acid → 8-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1)

HRID 573971

반응식

HRID 573971 반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[OH:11])[CH:4]=[CH:3][CH:2]=1.[ClH:12].[CH2:13]=O>O>[ClH:12].[Cl:12][CH2:13][C:6]1[CH:7]=[CH:8][C:9]([OH:11])=[C:10]2[C:5]=1[CH:4]=[CH:3][CH:2]=[N:1]2

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 712FormaldehydeHCID 19238-Hydroxyquinoline

생성물 1

HCID 122695968-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1)

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

A mixture of 14.6 g (0.1 mol) of 8-quinolinol, 16 mL of 32% HCl in water, and 16 mL (0.1 mL) of 37% formaldehyde in water at 0° C. was treated with hydrogen chloride gas for 6 h. The solution was allowed to stand at room temperature for 2 h without stirring. The yellow solid obtained was collected on a filter, washed with 90% alcohol and dried under vacuum to give 5-chloromethyl-8-quinolinol hydrochloride A (19.0 g, 98%): 1H NMR (250 MHz, CDCl3, δ) 5.32 (s, 2H), 7.53 (m, 1H), 7.85 (m, 2H), 8.12 (m, 1H), 9.12 (m, 1H), 9.28 (m, 1H).

후처리

  1. customThe yellow solid obtained
  2. customwas collected on a filter
  3. washwashed with 90% alcohol
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-208cc568f2f84b298b7cfeefc9fcb376
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034303B2

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