5-Chloro-2-methoxy-3-nitropyridine → 5-Chloro-2-methoxypyridin-3-amine

Zinc bromide (0.27 g, 1.2 mmol) and 10% platinum on carbon (0.58 g, 2.97 mmol) were added to a solution of 5-chloro-2-methoxy-3-nitropyridine (Preparation 6a, 1.13 g, 5.99 mmol) in ethyl acetate (20 mL) and the resulting mixture was hydrogenated in a Parr apparatus at 10 psi for 2 hours. The mixture was then filtered through diatomaceous earth (Celite®) and the filter cake was washed with ethyl acetate. The combined filtrate and washings were concentrated to give the title compound (0.95 g, 100%) as an oil which was used in the next synthetic step without further purification.

1. filtrationThe mixture was then filtered through diatomaceous earth (Celite®)
2. washthe filter cake was washed with ethyl acetate
3. concentrationThe combined filtrate and washings were concentrated

ORD 기록

ord-9a2fd9244b1a4588b7db39fc72aff918

출처 데이터셋

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09034311B2