Thionyl Chloride → 2-(Chloromethyl)-4H-1-benzopyran-4-one

HRID 574123노트

반응식

HRID 574123 반응식
O[CH2:2][C:3]1[O:4][C:5]2[C:10]([C:11](=[O:13])[CH:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.S(Cl)([Cl:16])=O>C(Cl)(Cl)Cl>[Cl:16][CH2:2][C:3]1[O:4][C:5]2[C:10]([C:11](=[O:13])[CH:12]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 12536095HCID 12536095, 화합물

생성물 1

HCID 140019552-(Chloromethyl)-4H-1-benzopyran-4-one

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

The 2-(hydroxymethyl)-4H-chromen-4-one was dissolved in 30 ml of anhydrous chloroform at room temperature, 1 ml of thionyl chloride was added to the solution, and reaction mixture was stirred at room temperature for 24 hours. The solvent was thereafter evaporated, and the obtained liquid was dissolved in anhydrous hexane, which was also evaporated again to give 2-(chloromethyl)-4H-chromen-4-one which was further reacted without purification.

후처리

  1. customThe solvent was thereafter evaporated
  2. dissolutionthe obtained liquid was dissolved in anhydrous hexane
  3. customwhich was also evaporated again

출처 및 근거

ORD 기록
ord-31677ca7dbbc4e74bc58de3ddaf5d14c
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034872B2

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