4-tert-Butylcyclohexanone → 1-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

HRID 574135

반응식

HRID 574135 반응식
[C:1]([CH:5]1[CH2:10][CH2:9][C:8](=O)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[NH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([CH:5]1[CH2:10][CH2:9][C:8]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)=[CH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 73924-tert-ButylcyclohexanoneHCID 31268Pyrrolidine

생성물 1

HCID 1072321-[4-(Tert-butyl)-1-cyclohexen-1-YL]pyrrolidine

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A 50 mL round-bottomed flask containing 4-tert-butylcyclohexanone (6.01 gm) in anhydrous toluene (20 mL) was fitted with a Dean-Stark trap containing 3 A molecular sieves, reflux condenser and a heating mantle. Pyrrolidine (6.00 mL) was added, and the solution heated to reflux for 18 hr. The solvent was evaporated and the crude product was used directly for the next reaction.

후처리

  1. customwas fitted with a Dean-Stark trap
  2. additioncontaining 3 A molecular sieves
  3. temperaturereflux condenser
  4. temperaturethe solution heated
  5. temperatureto reflux for 18 hr
  6. customThe solvent was evaporated
  7. customthe crude product was used directly for the next reaction

출처 및 근거

ORD 기록
ord-1dfc076b8c0246ffa08371707ff08b15
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034871B2

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