Water → 6-(Pyridin-2-yl)pyridazine-3-thiol

HRID 574183

반응식

HRID 574183 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=O)[NH:11][N:12]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:15].O>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=[S:15])[NH:11][N:12]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 49800226-(Pyridin-2-yl)pyridazin-3-ol

생성물 1

HCID 49800236-(Pyridin-2-yl)pyridazine-3-thiol수율 92%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

500 mg (2.9 mmol) of pyridazinone 7 and 772 mg (3.5 mmol) of phosphorus pentasulfide are dissolved in 20 ml of anhydrous pyridine. The reaction mixture is brought to reflux for 18 h, and then cooled to ambient temperature. It is then poured into 200 ml of water, and the precipitate thus formed is filtered off and then washed with ice-cold water. The pyridazinethione 10 is obtained with a yield of 92%.

후처리

  1. temperatureto reflux for 18 h
  2. customthe precipitate thus formed
  3. filtrationis filtered off
  4. washwashed with ice-cold water

출처 및 근거

ORD 기록
ord-ee53a89773d24a1ea64a87dac1a80651
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034873B2

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