Diethyl Ether → HCID 178418743, 화합물

HRID 574696

반응식

HRID 574696 반응식
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][OH:11])=[CH:9][C:4]=2[N:3]=[CH:2]1.C[N+]1([O-])CCOCC1.CCOCC>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 82029Methyl morpholine oxideHCID 178519339HCID 178519339, 화합물

생성물 1

HCID 178418743HCID 178418743, 화합물

시약·촉매·용매 2

HCID 178419074HCID 178419074, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

(1H-benzo[d]imidazole-5-yl)methanol (2.8 mmol, 1 eq.) was dissolved in 30 mL dichloromethane and a molecular sieve (4 A) was added. To the solution were added Tetrapropylammonium perruthenate (0.28 mmol, 0.1 eq.) and N-Methylmorpholine-N-Oxide (9.8 mmol, 3.5 eq.). After stirring the mixture for 72 hours at room temperature 50 mL of ether was added and filtrated. The solvent was removed under reduced pressure and the product was purified by means of flash-chromatography using silica gel and a ethyl acetate/MeOH-gradient.

후처리

  1. additiona molecular sieve (4 A) was added
  2. additionwas added
  3. filtrationfiltrated
  4. customThe solvent was removed under reduced pressure
  5. customthe product was purified by means of flash-chromatography

출처 및 근거

ORD 기록
ord-12dc541905d04133a437a9cab93dbb56
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034907B2

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