Sodium Hydroxide → [4-[Cyclopropyl(oxetan-3-yl)amino]cyclohexyl]methanol

HRID 574918노트

반응식

HRID 574918 반응식
[CH:1]1([N:4]([CH:16]2[CH2:19][O:18][CH2:17]2)[CH:5]2[CH2:10][CH2:9][CH:8]([C:11](OCC)=[O:12])[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1.C(OCC)(=O)C>[CH:1]1([N:4]([CH:16]2[CH2:19][O:18][CH2:17]2)[CH:5]2[CH2:6][CH2:7][CH:8]([CH2:11][OH:12])[CH2:9][CH2:10]2)[CH2:2][CH2:3]1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 67126835Ethyl 4-[cyclopropyl(oxetan-3-yl)amino]cyclohexane-1-carboxylate

생성물 1

HCID 67126731[4-[Cyclopropyl(oxetan-3-yl)amino]cyclohexyl]methanol

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of EXAMPLE 329B (1.2 g) in tetrahydrofuran (20 mL) was added lithium aluminum hydride (0.681 g). The mixture was stirred overnight. 2N aqueous NaOH solution was added dropwise to the reaction mixture. The mixture was then diluted with ethyl acetate (300 mL) and washed with water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

후처리

  1. washwashed with water, brine
  2. dry with materialdried over Na2SO4
  3. filtrationFiltration and evaporation of the solvent

출처 및 근거

ORD 기록
ord-13101f105b4643f5bc8221cb06617b5c
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034875B2

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