Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → Methyl 1,4-dioxaspiro[4.5]decane-7-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 반응물 | Methyl 3-oxocyclohexane-1-carboxylate | HCID 566099 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Methyl 1,4-dioxaspiro[4.5]decane-7-carboxylate | HCID 372311 | — |
반응 단계
Methyl 3-oxocyclohexanecarboxylate (930 mg) and pyridinium p-toluenesulfonate (299 mg) were combined in toluene (29.8 mL) to give a colorless solution. Ethylene glycol (0.996 mL) was added and the reaction was refluxed under Dean-Stark conditions for 2 days. The reaction was cooled to room temperature, triethylamine was added, and then the mixture was concentrated by rotary evaporation. The residue was purified by regular phase flash column chromatography (Analogix 0-40% hexane/ethyl acetate).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09034875B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-89ae61a478bb4ddc8bfe5bc0a9a34275 |
| 출처 메모 | uspto-grants-2015_05 |