反应详情

Methyl 3-oxocyclohexanecarboxylate (930 mg) and pyridinium p-toluenesulfonate (299 mg) were combined in toluene (29.8 mL) to give a colorless solution. Ethylene glycol (0.996 mL) was added and the reaction was refluxed under Dean-Stark conditions for 2 days. The reaction was cooled to room temperature, triethylamine was added, and then the mixture was concentrated by rotary evaporation. The residue was purified by regular phase flash column chromatography (Analogix 0-40% hexane/ethyl acetate).

1. customto give a colorless solution
2. temperaturethe reaction was refluxed under Dean-Stark conditions for 2 days
3. concentrationthe mixture was concentrated by rotary evaporation
4. customThe residue was purified by regular phase flash column chromatography (Analogix 0-40% hexane/ethyl acetate)