Ethanol → 5,7-Dichloropyrido(3,4-b)pyrazine
반응식
[Cl:1][C:2]1[C:7]([NH2:8])=[C:6]([NH2:9])[CH:5]=[C:4]([Cl:10])[N:3]=1.O.[CH2:12](O)[CH3:13]>C(C=O)=O>[Cl:1][C:2]1[C:7]2[C:6](=[N:9][CH:12]=[CH:13][N:8]=2)[CH:5]=[C:4]([Cl:10])[N:3]=1참가 물질
5
실험 절차
A mixture of the solution of 2,6-dichloropyridine-3,4-diamine (7.85 g, 0.044 mol) in ethanol and 40% glyoxal solution in water (26 g, 0.178 mol) was refluxed overnight. It was then cooled to ambient temperature, and the precipitates were collected, washed with EtOH, and dried in vacuo to give the title compound (7.32 g, 83% yield).
후처리
- temperaturewas refluxed overnight
- customthe precipitates were collected
- washwashed with EtOH
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-b9dfa39a33924e5292e17cc294459ad9
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434726B2
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