Dimethylamine → 4-((N,N-Dimethylamino)methyl)phenylboronic acid pinacol ester

HRID 57518

반응식

HRID 57518 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:5][CH:4]=1.[NH:18]([CH3:20])[CH3:19]>C1COCC1>[CH3:19][N:18]([CH3:20])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]2[O:13][C:12]([CH3:15])([CH3:14])[C:11]([CH3:17])([CH3:16])[O:10]2)=[CH:5][CH:4]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 37345062-(4-(Bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

생성물 1

HCID 34604594-((N,N-Dimethylamino)methyl)phenylboronic acid pinacol ester

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 2-(4-(bromomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (200 mg, 0.673 mmol) and aqueous Me2NH (4 mL) in THF (10 mL) was stirred at room temperature overnight. It was then concentrated under reduced pressure to give the title compound. MS (m/z): 262 (M+H)+.

후처리

  1. concentrationIt was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-acbd8a8c17224c1387a500bd99a71009
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

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