Methylamine → N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

HRID 57523

반응식

HRID 57523 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)=[CH:4][N:3]=1.CN.C[CH2:20][N:21](C(C)C)C(C)C>O1CCOCC1>[CH3:20][NH:21][C:2]1[CH:7]=[CH:6][C:5]([B:8]2[O:12][C:11]([CH3:14])([CH3:13])[C:10]([CH3:16])([CH3:15])[O:9]2)=[CH:4][N:3]=1

참가 물질

5

반응물 3

HCID 6329MethylamineHCID 81531DiisopropylethylamineHCID 27947192-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

생성물 1

HCID 56686504N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (200 mg, 0.84 mmol), methanamine (277 mg, 8.4 mmol), and DIPEA (0.35 mL, 2.01 mmol) in dioxane (5 mL) was stirred at room temperature for 16 hours. It was then concentrated under reduced pressure, and the residue was treated in EtOAc. The insoluble solid was removed by filtration, and the organic solution was concentrated under reduced pressure to give the title compound.

후처리

  1. concentrationIt was then concentrated under reduced pressure
  2. additionthe residue was treated in EtOAc
  3. customThe insoluble solid was removed by filtration
  4. concentrationthe organic solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9a28bae1fc6a40d8874fa0fae747a213
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

연결된 노트

불러오는 중…