Ethyl Bromide → N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

HRID 57525

반응식

HRID 57525 반응식
[CH3:1][C:2]1([CH3:16])[C:6]([CH3:8])([CH3:7])[O:5][B:4]([C:9]2[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=2)[O:3]1.Br[CH2:18][CH3:19].[H-].[Na+].[CH2:22]1COC[CH2:23]1>>[CH2:22]([N:15]([CH2:18][CH3:19])[C:12]1[CH:13]=[CH:14][C:9]([B:4]2[O:3][C:2]([CH3:16])([CH3:1])[C:6]([CH3:7])([CH3:8])[O:5]2)=[CH:10][CH:11]=1)[CH3:23]

참가 물질

5

반응물 4

HCID 6332Ethyl BromideHCID 8028TetrahydrofuranHCID 24758Sodium hydrideHCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

생성물 1

HCID 44629855N,N-Diethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

실험 절차

A mixture of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine (100 mg, 0.45 mmol) and bromoethane (200 mg, 1.8 mmol), NaH (100 mg, 1.8 mmol) in THF was stirred at room temperature overnight, and concentrated in vacuo to give the crude title compound used for the next step. MS (m/z): 276 (M+H)+.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d87bad50eb66433bb162f6a1119d5ebd
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

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