4,4-Difluorocyclohexan-1-amine hydrochloride → HCID 86693307, 화합물

HRID 575279

반응식

HRID 575279 반응식
[OH:1][C@:2]([C:32]1[CH:36]=[C:35]([CH3:37])[O:34][N:33]=1)([CH3:31])[C:3]#[C:4][C:5]1[CH:6]=[CH:7][C:8]2[O:14][CH2:13][CH2:12][N:11]3[C:15]([C:21]([NH:23][CH:24]4[CH2:29][CH2:28]O[CH2:26][CH2:25]4)=[O:22])=[C:16]([C:18]([NH2:20])=[O:19])[N:17]=[C:10]3[C:9]=2[CH:30]=1.Cl.NC1CC[C:43]([F:47])([F:46])CC1>>[F:46][C:43]1([F:47])[CH2:28][CH2:29][CH:24]([NH:23][C:21]([C:15]2[N:11]3[CH2:12][CH2:13][O:14][C:8]4[CH:7]=[CH:6][C:5]([C:4]#[C:3][C@@:2]([OH:1])([C:32]5[CH:36]=[C:35]([CH3:37])[O:34][N:33]=5)[CH3:31])=[CH:30][C:9]=4[C:10]3=[N:17][C:16]=2[C:18]([NH2:20])=[O:19])=[O:22])[CH2:25][CH2:26]1

참가 물질

3

반응물 2

HCID 231506694,4-Difluorocyclohexan-1-amine hydrochlorideHCID 86693302(R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide

생성물 1

HCID 86693307HCID 86693307, 화합물

실험 절차

Prepared as described for (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide replacing 4-aminotetrahydropyran with 4-amino-1,1-difluorocyclohexane hydrochloride. Off-white solid 40.2 mg, 12%).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-839aee90a22248d68b2708fc93d14653
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09034866B2

연결된 노트

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