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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 575279생성일: 2026년 10월 25일

4,4-Difluorocyclohexan-1-amine hydrochloride → (R)-N3-(4,4-difluorocyclohexyl)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide

https://huagongshe.com/reaction/575279

반응식

참여 물질

역할이름HCID투입량
반응물4,4-Difluorocyclohexan-1-amine hydrochlorideHCID 23150669—
반응물(R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamideHCID 86693302—
생성물(R)-N3-(4,4-difluorocyclohexyl)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamideHCID 86693307—

반응 단계

Prepared as described for (R)-10-(3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-yn-1-yl)-N3-(tetrahydro-2H-pyran-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2,3-dicarboxamide replacing 4-aminotetrahydropyran with 4-amino-1,1-difluorocyclohexane hydrochloride. Off-white solid 40.2 mg, 12%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09034866B2
출처 데이터셋uspto-grants-2015_05
ORD IDord-839aee90a22248d68b2708fc93d14653
출처 메모uspto-grants-2015_05