Sodium Hydroxide → 1-(4-Nitrophenyl)piperidine-4-carboxylic acid

HRID 57573

반응식

HRID 57573 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([C:16]([O:18]C)=[O:17])[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[OH-].[Na+]>CO.O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:11][CH2:12][CH:13]([C:16]([OH:18])=[O:17])[CH2:14][CH2:15]2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 345002Methyl 1-(4-nitrophenyl)piperidine-4-carboxylate

생성물 1

HCID 27672651-(4-Nitrophenyl)piperidine-4-carboxylic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of methyl 1-(4-nitrophenyl)piperidine-4-carboxylate (3.84 g, 14.53 mmol) and NaOH (0.87 g, 21.79 mmol) in 15 mL of MeOH and 5 mL of water was stirred at room temperature for 3 hours. The volatiles were removed in vacuo to give 1-(4-nitrophenyl)piperidine-4-carboxylic acid.

후처리

  1. customThe volatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-00fa39b73d6247129b757153de89aac4
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434726B2

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