Sodium Hydroxide → Benzeneacetic acid, 4-(1,1-dimethylethyl)-

HRID 576057

반응식

HRID 576057 반응식
C[O:2][C:3](=[O:15])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:7][CH:6]=1.[OH-].[Na+]>O1CCCC1.CO>[C:11]([C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:15])=[O:2])=[CH:6][CH:7]=1)([CH3:14])([CH3:12])[CH3:13]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 605629Methyl p-tert-butylphenylacetate

생성물 1

HCID 118343Benzeneacetic acid, 4-(1,1-dimethylethyl)-수율 100%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 4-tert-butylphenyl acetic acid methyl ester (10.0 g, 48.5 mmol) in a mixture of tetrahydrofuran (50 mL) and methanol (50 mL) was added 6 mol/L aqueous sodium hydroxide solution (16.2 mL, 97.0 mmol), and the mixture was stirred at room temperature for 3 hr. The mixture was concentrated under reduced pressure and 6 mol/L hydrochloric acid was added thereto while cooling in ice, to adjust the pH to 4 to 5. A precipitated solid was collected by filtration to afford (4-tert-butylphenyl)acetic acid as a colorless powder (9.32 g).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure and 6 mol/L hydrochloric acid
  2. additionwas added
  3. temperaturewhile cooling in ice
  4. filtrationA precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-9b4cfe33a62c4417adb267e56b827bf3
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09035059B2

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