Sodium borohydride → (S)-tert-butyl 3-(1-hydroxyethyl)pyrrolidine-1-carboxylate
반응식
[C:1]([C@H:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5]1)(=[O:3])[CH3:2].[BH4-].[Na+]>CO>[OH:3][CH:1]([C@H:4]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:13])([CH3:15])[CH3:14])=[O:10])[CH2:5]1)[CH3:2]참가 물질
4
실험 절차
To a solution of (S)-tert-butyl 3-acetylpyrrolidine-1-carboxylate in methanol (10 mL) was added sodium borohydride (114 mg, 3.0 mmol) at 0° C. The reaction mixture was stirred at ambient temperature for 2 hours then quenched with saturated ammonium chloride solution and extracted with dichloromethane. The combined extracts were dried over magnesium sulfate, filtered, and concentrated to give the title compound for the next step.
후처리
- customthen quenched with saturated ammonium chloride solution
- extractionextracted with dichloromethane
- dry with materialThe combined extracts were dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-4fb5d22d6b59418ba567344c09e3fb35
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434726B2
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