Hydrochloric Acid → 6-[(2-Aminoethyl)amino]nicotinonitrile dihydrochloride

HRID 57662노트

반응식

HRID 57662 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)=[N:7][CH:8]=1)#[N:2].[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[NH2:12][CH2:11][CH2:10][NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:8][N:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 47453716tert-Butyl (2-((5-cyanopyridin-2-yl)amino)ethyl)carbamate

생성물 1

HCID 669113296-[(2-Aminoethyl)amino]nicotinonitrile dihydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

7.9 g (30 mmol) of tert-butyl {2-[(5-cyanopyridin-2-yl)amino]ethyl}carbamate (Example 1A) were dissolved in 100 ml of 4N hydrogen chloride in dioxane and the mixture was stirred for 30 min. The reaction mixture was concentrated to half of its original volume and the same amount of diethyl ether was added. The reaction mixture was stirred for 20 min and the product was filtered off and washed with diethyl ether. This gave 7 g (94% of theory) of the product as a solid.

후처리

  1. concentrationThe reaction mixture was concentrated to half of its original volume
  2. additionthe same amount of diethyl ether was added
  3. stirringThe reaction mixture was stirred for 20 min
  4. filtrationthe product was filtered off
  5. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-ec57fb72d52b4461a22af45787817304
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434731B2

반응 노트

불러오는 중…