Hydrazine hydrate (1:1) → 5-Bromopyrimidine-2-carbohydrazide

HRID 576703

반응식

HRID 576703 반응식
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]([O:10]C)=O)=[N:6][CH:7]=1.O.[NH2:13][NH2:14]>CCO>[Br:1][C:2]1[CH:7]=[N:6][C:5]([C:8]([NH:13][NH2:14])=[O:10])=[N:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 45790831Methyl 5-bromopyrimidine-2-carboxylate

생성물 1

HCID 139542395-Bromopyrimidine-2-carbohydrazide수율 72.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a slurry of methyl 5-bromopyrimidine-2-carboxylate (1.0 g, 4.6 mmol) in EtOH (3.6 mL) was added hydrazine monohydrate (0.46 mL, 9.2 mmol). The reaction mixture was stirred at rt for 1 h. The mixture was filtered, and the collected solid was washed with additional EtOH to provide the desired product as a beige solid (720 mg, 72%). MS (ESI): mass calcd. for C5H5N4O, 216.0; m/z found, 217.0 [M+H]+. 1H NMR (500 MHz, DMSO-d6) δ 10.15 (s, 1H), 9.18-9.08 (s, 2H), 4.67 (s, 2H).

후처리

  1. filtrationThe mixture was filtered
  2. washthe collected solid was washed with additional EtOH

출처 및 근거

ORD 기록
ord-9c486243ddc64470ade7438153208e8c
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040534B2

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