Methylhydrazine → Ethyl 2-(1-methylhydrazinyl)acetate

HRID 576874노트

반응식

HRID 576874 반응식
[CH3:1][NH:2][NH2:3].C(N(CC)CC)C.Br[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>ClCCl.C(OCC)(=O)C>[CH3:1][N:2]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[NH2:3]

참가 물질

6

반응물 3

HCID 6061MethylhydrazineHCID 7748Ethyl bromoacetateHCID 8471Triethylamine

생성물 1

HCID 20288078Ethyl 2-(1-methylhydrazinyl)acetate수율 77.2%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of methylhydrazine 7.13 ml (150 mmol) and triethylamine 16.7 ml (120 mmol), ethyl 2-bromoacetate 16.7 g (100 mmol) in dichloromethane 50 ml was added and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate 300 ml and washed with brine 200 ml. The organic phase was dried over magnesium sulfate and filtered and the mother solution was concentrated in vacuo to obtain the title compound 10.2 g (77%).

후처리

  1. washwashed with brine 200 ml
  2. dry with materialThe organic phase was dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationthe mother solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-55b3a420a88f4d3b88cd052751607f87
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040531B2

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