Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus tribromide → 3-(Bromomethyl)quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | (Quinolin-3-yl)methanol | HCID 12662983 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-(Bromomethyl)quinoline | HCID 23510331 | — |
반응 단계
Quinolin-3-ylmethanol was dissolved dichloromethane (15 mL) at 0° C. under nitrogen. Tribromophosphane (2.15 mL, 22 mmol) was added dropwise. The resulting mixture was stirred at room temperature overnight. The reaction was quenched by addition of 10% NaHCO3 solution (5 mL). After 10 minutes, Na2SO4 (30 g) was added. The solvent was filtered and evaporated to provide 3-(bromomethyl)quinoline, which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09040538B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-bf1bb2d7b0d3480a847ced8e57081458 |
| 출처 메모 | uspto-grants-2015_05 |