Phosphorus tribromide → 5-(Bromomethyl)-2,4-dichloro-1,3-thiazole

HRID 577005노트

반응식

HRID 577005 반응식
[Cl:1][C:2]1[S:3][C:4]([CH2:8]O)=[C:5]([Cl:7])[N:6]=1.P(Br)(Br)[Br:11]>ClCCl>[Br:11][CH2:8][C:4]1[S:3][C:2]([Cl:1])=[N:6][C:5]=1[Cl:7]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 10375112(Dichloro-1,3-thiazol-5-yl)methanol

생성물 1

HCID 223492195-(Bromomethyl)-2,4-dichloro-1,3-thiazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (2,4-dichloro-1,3-thiazol-5-yl)methanol (850 mg, 4.6 mmol) in anhydrous dichloromethane (40 mL) was added dropwise phosphorus tribromide (850 μL, 9.2 mmol). The mixture was stirred at room temperature for 3 hours. The solvent was evaporated. The residue was dried in vacuo, affording 5-(bromomethyl)-2,4-dichloro-1,3-thiazole. The product was used without further purification.

후처리

  1. customThe solvent was evaporated
  2. customThe residue was dried in vacuo

출처 및 근거

ORD 기록
ord-3db8893feb1e42af9177b8c669c77f48
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

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