1,2-dimethyl-1H-imidazole-5-carbaldehyde → (1,2-dimethyl-1H-imidazol-5-yl)methanol

HRID 577056

반응식

HRID 577056 반응식
[BH4-].[Na+].[CH3:3][N:4]1[C:8]([CH:9]=[O:10])=[CH:7][N:6]=[C:5]1[CH3:11]>CO>[CH3:3][N:4]1[C:8]([CH2:9][OH:10])=[CH:7][N:6]=[C:5]1[CH3:11]

참가 물질

4

반응물 2

HCID 31596101,2-dimethyl-1H-imidazole-5-carbaldehydeHCID 4311764Sodium borohydride

생성물 1

HCID 304328(1,2-dimethyl-1H-imidazol-5-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of sodium borohydride (457 mg, 12.1 mmol) in methanol (25 mL) was added a solution of 1,2-dimethyl-1H-imidazole-5-carbaldehyde (1.0 g, 8.1 mmol) in methanol (10 mL) at 0° C. The mixture was stirred overnight at room temperature. The solvent was evaporated, and crude (1,2-dimethyl-1H-imidazol-5-yl)methanol was obtained and used in the next step without purification; 1H NMR (400 MHz, DMSO-d6): δ 2.22 (s, 3H), 3.45 (s, 3H), 4.34 (s, 2H), 5.05 (bs, 1H), 6.57 (s, 1H).

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-63b352a81eb04310afa36092701361f7
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040538B2

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