Phosphorus tribromide → 5-(Bromomethyl)-4-(propan-2-yl)-1,3-thiazole
반응식
[CH3:1][CH:2]([C:4]1[N:5]=[CH:6][S:7][C:8]=1[CH2:9]O)[CH3:3].[Br:11]P(Br)Br>ClCCl>[Br:11][CH2:9][C:8]1[S:7][CH:6]=[N:5][C:4]=1[CH:2]([CH3:3])[CH3:1]참가 물질
4
실험 절차
To a solution of [4-(propan-2-yl)-1,3-thiazol-5-yl]methanol (800 mg, 5.1 mmol) in anhydrous dichloromethane (35 mL) was added tribromophosphane (520 μL, 5.5 mmol). The mixture was stirred at room temperature for 1.5 hours. Dichloromethane was evaporated. The residue was dried in vacuo, affording 5-(bromomethyl)-4-(propan-2-yl)-1,3-thiazole. The crude product was used without further purification.
후처리
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
출처 및 근거
- ORD 기록
- ord-44fb6159ddd54739a8b38ac094c740e3
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040538B2
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