Phosphorus tribromide → 4-(Bromomethyl)-3,5-dichloropyridine hydrobromide
반응식
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:10])[C:7]=1[CH2:8]O.[Br:11]P(Br)Br>ClCCl>[BrH:11].[Br:11][CH2:8][C:7]1[C:2]([Cl:1])=[CH:3][N:4]=[CH:5][C:6]=1[Cl:10]참가 물질
4
실험 절차
To a solution of (3,5-dichloropyridin-4-yl)methanol (1.9 g, 10.7 mmol) in anhydrous dichloromethane (75 mL) was added tribromophosphane (1.1 mL, 11.5 mmol). The mixture was stirred at room temperature for 1.5 hours. Dichloromethane was evaporated, and the mixture was co-evaporated with toluene (2×20 mL). The residue was dried in vacuo, affording 4-(bromomethyl)-3,5-dichloropyridine hydrobromide (2.9 g, 98% yield), which was used without further purification.
후처리
- customDichloromethane was evaporated
- customThe residue was dried in vacuo
출처 및 근거
- ORD 기록
- ord-be2afbcb2c7a459583b1be10f1ac457a
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040538B2
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