Diisopropylethylamine → 3,6-dichloro-N-(2,3-difluorobenzyl)-1,2,4-triazin-5-amine
반응식
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[C:6](Cl)[N:7]=1.[F:10][C:11]1[C:18]([F:19])=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][NH2:14].CCN(C(C)C)C(C)C>CN1C(=O)CCC1.CCOC(C)=O>[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[C:6]([NH:14][CH2:13][C:12]2[CH:15]=[CH:16][CH:17]=[C:18]([F:19])[C:11]=2[F:10])[N:7]=1참가 물질
6
실험 절차
3,5,6-Trichloro-1,2,4-triazine (520 mg, 2.8 mmol) was dissolved in 5 mL NMP. To it was added 2,3-difluorobenzylamine (0.36 mL, 3.1 mmol) and DIEA (0.54 mL, 3.1 mmol). The mixture was stirred at RT for 20 m. It was diluted with EtOAc, washed with brine twice, dried over MgSO4, concentrated in vacuo, and subjected to flash column to afford 3,6-dichloro-N-(2,3-difluorobenzyl)-1,2,4-triazin-5-amine.
후처리
- washwashed with brine twice
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-f8ebd8b6dd44423b9befa333174a86eb
- 출처 데이터셋
- uspto-grants-2015_05
- 특허 번호
- US09040530B2
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