Hydrochloric Acid → Methyl 3-bromo-6-(2-hydroxyethoxy)-2-methylbenzoate

HRID 577569노트

반응식

HRID 577569 반응식
[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:9]([O:12][CH2:13][CH2:14][O:15]C2CCCCO2)=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].Cl>CO>[Br:1][C:2]1[C:3]([CH3:22])=[C:4]([C:9]([O:12][CH2:13][CH2:14][OH:15])=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86723693methyl 3-bromo-2-methyl-6-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]benzoate

생성물 1

HCID 86723795Methyl 3-bromo-6-(2-hydroxyethoxy)-2-methylbenzoate수율 110%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of methyl 3-bromo-2-methyl-6-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]-benzoate (Cpd HH, 162 mg, 0.434 mmol) in MeOH (4 mL) was treated with 6N HCl (0.2 mL) and stirred at room temperature for 30 minutes. The solvent was concentrated in vacuum to 1 mL and the solution partitioned between DCM (25 mL) and NaHCO3 (sat., aq., 25 mL). The organic layer was concentrated under vacuum to give methyl 3-bromo-6-(2-hydroxyethoxy)-2-methylbenzoate (126a, 138 mg, 110% yield) as a colorless oil.

후처리

  1. concentrationThe solvent was concentrated in vacuum to 1 mL
  2. customthe solution partitioned between DCM (25 mL) and NaHCO3 (sat., aq., 25 mL)
  3. concentrationThe organic layer was concentrated under vacuum

출처 및 근거

ORD 기록
ord-82e81d7a35d043ebabf23995d0eabdc3
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040515B2

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