Ethyl isothiocyanatoformate → Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate

HRID 57762

반응식

HRID 57762 반응식
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:9]([O:11][C:12]([N:14]=[C:15]=[S:16])=[O:13])[CH3:10]>ClCCl>[Br:8][C:7]1[C:2]([NH:1][C:15]([NH:14][C:12](=[O:13])[O:11][CH2:9][CH3:10])=[S:16])=[N:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 85320Ethyl isothiocyanatoformateHCID 8177002-Amino-3-bromopyridine

생성물 1

HCID 59199107Ethyl aminon-(3-bromopyridin-2-YL)methanethiocarbamate수율 100.1%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-amino-3-bromopyridine (50.0 g, 289 mmol, 1 equiv) in dichloromethane (500 mL) was added dropwise ethoxycarbonyl isothiocyanate (39.0 g, 297 mmol, 1.03 equiv) at room temperature. After 2 h, dichloromethane was removed in vacuo to provide crude ethyl [(3-bromopyridin-2-yl) carbamothioyl]carbamate (88 g).

후처리

  1. customdichloromethane was removed in vacuo

출처 및 근거

ORD 기록
ord-3f38827b80af4bdb9a6ae3cdfa4213f7
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434732B2

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