Hydrochloric Acid → 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 577735

반응식

HRID 577735 반응식
[OH-].[K+].[CH3:3][N:4]([CH3:19])[CH2:5][CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([O:15]CC)=[O:14])[N:10]([CH3:18])[N:9]=1.Cl>CCO>[CH3:3][N:4]([CH3:19])[CH2:5][CH2:6][O:7][C:8]1[CH:12]=[C:11]([C:13]([OH:15])=[O:14])[N:10]([CH3:18])[N:9]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 86679667ethyl 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylate

생성물 1

HCID 866796683-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid수율 83%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

KOH (2.09 g, 37.4 mmol) was dissolved into EtOH (30 mL) and to this solution was added ethyl 3-(2-(dimethylamino)ethoxy)-1-methyl-1H-pyrazole-5-carboxylate (4.5 g, 18.7 mmol) and the mixture stirred at rt overnight. To the reaction mixture was added concentrated HCl (3.1 mL) with stirring and the resulting suspension was filtered and the cake was washed with EtOH (two×20 mL). The filtrate was concentrated to give the title compound (3.3 g, 83% yield) as a brown gum.

후처리

  1. stirringwith stirring
  2. filtrationthe resulting suspension was filtered
  3. washthe cake was washed with EtOH (two×20 mL)
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-4cbb75141e2b445bbc33bf5a0397755d
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040547B2

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