Sodium hydride → Ethyl 5-((tert-butyldiphenylsilyloxy)methyl)-7-chloro-6-((2R,6S)-2,6-dimethylmorpholino)isoxazolo[4,5-b]pyridine-3-carboxylate

반응식

[H-].[Na+].[Si:3]([O:20][CH2:21][C:22]1[N:27]=[C:26]([C:28](=[N:34][OH:35])[C:29]([O:31][CH2:32][CH3:33])=[O:30])[C:25](F)=[C:24]([Cl:37])[C:23]=1[N:38]1[CH2:43][C@H:42]([CH3:44])[O:41][C@H:40]([CH3:45])[CH2:39]1)([C:16]([CH3:19])([CH3:18])[CH3:17])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH4+].[Cl-]>CN(C=O)C>[Si:3]([O:20][CH2:21][C:22]1[N:27]=[C:26]2[C:28]([C:29]([O:31][CH2:32][CH3:33])=[O:30])=[N:34][O:35][C:25]2=[C:24]([Cl:37])[C:23]=1[N:38]1[CH2:43][C@H:42]([CH3:44])[O:41][C@H:40]([CH3:45])[CH2:39]1)([C:16]([CH3:19])([CH3:18])[CH3:17])([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1