Anisole → 6-(5-ethyl-3-pyridyl)-1H-pyrazolo[4,3-c]pyridine

HRID 57828노트

반응식

HRID 57828 반응식
[CH2:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:14]=[CH:13][C:12]3[CH:15]=[N:16][N:17](COCC[Si](C)(C)C)[C:11]=3[CH:10]=2)[CH:6]=[N:7][CH:8]=1)[CH3:2].C1(OC)C=CC=CC=1.O1CCOCC1>Cl>[CH2:1]([C:3]1[CH:4]=[C:5]([C:9]2[N:14]=[CH:13][C:12]3[CH:15]=[N:16][NH:17][C:11]=3[CH:10]=2)[CH:6]=[N:7][CH:8]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 7519AnisoleHCID 312751,4-DioxaneHCID 867070332-[[6-(5-Ethyl-3-pyridyl)pyrazolo[4,3-c]pyridin-1-yl]methoxy]ethyl-trimethyl-silane

생성물 1

HCID 867070346-(5-ethyl-3-pyridyl)-1H-pyrazolo[4,3-c]pyridine수율 174.1%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 2-[[6-(5-ethyl-3-pyridyl)pyrazolo[4,3-c]pyridin-1-yl]methoxy]ethyl-trimethyl-silane (0.2456 mmol; 106.8 mg) and anisole (1.228 mmol; 133 mg; 0.134 ml) in hydrogen chloride, 4.0 M in 1,4-dioxane (20 mmol; 5 ml) was stirred at room temperature overnight. The mixture was concentrated to afford 6-(5-ethyl-3-pyridyl)-1H-pyrazolo[4,3-c]pyridine (˜95.9 mg), which was used without purification.

후처리

  1. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-96f707140a3f498083b7d2e34fcf2110
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434725B2

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