Hydrochloric Acid → HCID 66763587, 화합물

HRID 578619노트

반응식

HRID 578619 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH:15]C(=O)OC(C)(C)C)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1.Cl>CO>[CH3:1][O:2][CH2:3][CH2:4][CH:5]([NH2:15])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 68096871HCID 68096871, 화합물

생성물 1

HCID 66763587HCID 66763587, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of tert-butyl [3-methoxy-1-(3-nitrophenyl)propyl]carbamate (1.5 g; 4.83 mmol; 1.00 eq.) in MeOH (2 mL) was added hydrogen chloride (12.08 ml; 4.00 M; 48.33 mmol; 10.00 eq.). The mixture was stirred for 2 h. After removal of the solvent, the residue was diluted with EtOAc, washed with K2CO3 solution, dried and concentrated. The crude product (1.0 g) was used as such for the next reaction without purification. LCMS [211 (M+1)].

후처리

  1. customAfter removal of the solvent
  2. additionthe residue was diluted with EtOAc
  3. washwashed with K2CO3 solution
  4. customdried
  5. concentrationconcentrated
  6. customsuch for the next reaction
  7. customwithout purification

출처 및 근거

ORD 기록
ord-afdbfa23477c404cbb68bdebfc1bb53b
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040560B2

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