Hydrochloric Acid → 2-acetamido-N-tert-butyl-2-(2-(1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexanamide

HRID 579536노트

반응식

HRID 579536 반응식
[C:1]([NH:4][C:5]([C:38](=[O:44])[NH:39][C:40]([CH3:43])([CH3:42])[CH3:41])([CH2:25][CH2:26][CH2:27][CH2:28][B:29]1[O:33][C:32]([CH3:35])([CH3:34])[C:31]([CH3:37])([CH3:36])[O:30]1)[CH2:6][CH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][N:9]1C(OC(C)(C)C)=O)(=[O:3])[CH3:2].Cl>C(OCC)(=O)C>[C:1]([NH:4][C:5]([CH2:6][CH2:7][CH:8]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10][NH:9]1)([CH2:25][CH2:26][CH2:27][CH2:28][B:29]1[O:30][C:31]([CH3:36])([CH3:37])[C:32]([CH3:34])([CH3:35])[O:33]1)[C:38]([NH:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66833409tert-butyl 3-(3-acetamido-3-(tert-butylcarbamoyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)heptyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

생성물 1

HCID 668337032-acetamido-N-tert-butyl-2-(2-(1,2,3,4-tetrahydroisoquinolin-3-yl)ethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)hexanamide

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

A solution of tert-butyl 3-(3-acetamido-3-(tert-butylcarbamoyl)-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)heptyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in ethyl acetate was treated with a solution of HCl (g) in ethyl acetate (approximately 2 M). After stirring for 30 min the reaction was concentrated to dryness and the crude hydrochloride product was used without further purification.

후처리

  1. concentrationwas concentrated to dryness
  2. customthe crude hydrochloride product was used without further purification

출처 및 근거

ORD 기록
ord-e1cc7bd7acb54984902755d39568f990
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040703B2

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