Lithium Hydroxide → 2-Cyclohexyl-1,3-thiazole-4-carboxylic acid

HRID 579654노트

반응식

HRID 579654 반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[S:9][CH:10]=1)=[O:5])C.[Li+].[OH-]>O>[CH:11]1([C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 57956421Ethyl 2-cyclohexylthiazole-4-carboxylate

생성물 1

HCID 234049342-Cyclohexyl-1,3-thiazole-4-carboxylic acid수율 83%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 2-cyclohexylthiazole-4-carboxylic acid ethyl ester (116, 6.8 g, 28.5 mmol) in water was added 1M LiOH (50 mL). The solution was kept at room temperature and monitored by LC-MS. When the hydrolysis was completed the reaction mixture was neutralized with myriatic acid and extracted with ethyl acetate and diethyl ether. The organic phase was dried (Na2SO4), filtered and concentrated under reduced pressure to give 5.0 g (83%) of the title compound 117: m/z=212 (M+H)+.

후처리

  1. customwas kept at room temperature
  2. extractionextracted with ethyl acetate and diethyl ether
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c8262375e329495db3455a46749e641c
출처 데이터셋
uspto-grants-2015_05
특허 번호
US09040562B2

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