Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 579788생성일: 2026년 10월 26일
2-(Methylthio)thiazolo[5,4-b]pyridine → 1-acetyl-N-(thiazolo[5,4-b]pyridin-2-yl)-4-piperidinemethanamine
https://huagongshe.com/reaction/579788
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Methylthio)thiazolo[5,4-b]pyridine | HCID 699840 | — |
| 반응물 | 2,3-Dihydro-1,4-benzodioxin-6-yl isothiocyanate | HCID 2776173 | — |
| 반응물 | 1-(4-(Aminomethyl)piperidin-1-yl)ethan-1-one | HCID 12687022 | — |
| 생성물 | 1-acetyl-N-(thiazolo[5,4-b]pyridin-2-yl)-4-piperidinemethanamine | HCID 21241575 | 93% |
반응 단계
A mixture of 11 parts of 1-acetyl-4-piperidinemethanamine and 9 parts of 2-(methylthio)thiazolo[5,4-b]pyridine was stirred and heated for 20 hours at 140° C. The whole was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 13.5 parts (93%) of 1-acetyl-N-(thiazolo[5,4-b]-pyridin-2-yl)-4-piperidinemethanamine as a residue (intermediate 51).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04749702 |
|---|
| 출처 데이터셋 | uspto-grants-1988_06 |
|---|
| ORD ID | ord-18f857e80ac7404e92acdc90022a1021 |
|---|
| 출처 메모 | uspto-grants-1988_06 |
|---|
