tert-Butanol → HCID 54182549, 화합물

HRID 579830

반응식

HRID 579830 반응식
CCCCCCCCCCCCCCC.[C:16]([OH:20])([CH3:19])([CH3:18])[CH3:17].[C:21]([N:24]1[CH2:28][CH2:27][CH:26]=[CH:25]1)(=[O:23])[CH3:22].[O:29]1CCC[CH2:30]1>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[C:16]([O:20][C:30](=[O:29])[C@@H:25]1[CH2:26][CH2:27][CH2:28][N:24]1[C:21](=[O:23])[CH3:22])([CH3:19])([CH3:18])[CH3:17]

참가 물질

6

반응물 4

HCID 6386tert-ButanolHCID 8028TetrahydrofuranHCID 12391PentadecaneHCID 10909522N-Acetyl-2-pyrroline2회

생성물 1

HCID 54182549HCID 54182549, 화합물수율 1%

시약·촉매·용매 1

HCID 178418476HCID 178418476, 화합물촉매

반응 조건

온도
100 °C

실험 절차

A 70 mL stainless steel high pressure reactor having a Pyrex glass liner and a magnetic stir bar was charged with 5 mL of tetrahydrofuran, 0.5 mol of n-pentadecane internal standard, 0.5 mmol of tert-butyl alcohol, 40 mg of (PPh3)2PdCl2, and 55.5 mg of N-acetyl-2-pyrroline. The reactor was pressurized to 1000 psi with Co at room temperature, and the reaction mixture was stirred at 100° C. for 21 hours. Thereafter, the reactor was cooled to room temperature and vented to atmospheric pressure. The product mixture was analyzed by gas chromatography and mass spectrometry, and the analysis indicated 98.6% conversion of N-acetyl-2-pyrroline and 1.0% yield of N-acetylproline tert-butyl ester.

후처리

  1. customA 70 mL stainless steel high pressure reactor having
  2. customwas pressurized to 1000 psi with Co at room temperature
  3. temperatureThereafter, the reactor was cooled to room temperature

출처 및 근거

ORD 기록
ord-813b2ab7835346c8897922047801d6e1
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04749786

연결된 노트

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