Sodium Hydroxide → Benzyl(2-methylpropyl)amine

HRID 579839노트

반응식

HRID 579839 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH:7](=[N:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+]>CCOCC>[CH3:17][CH:16]([CH3:18])[CH2:15][NH:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 118050671-Propanamine, 2-methyl-N-(phenylmethylene)-HCID 21226445Aluminium lithium hydride

생성물 1

HCID 211729Benzyl(2-methylpropyl)amine수율 90.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a stirred solution of lithium aluminum hydride (23 g, 606 mmol) in ether (115 ml) was added an ethereal solution (115 ml) of N-benzylidene-2-methyl-1-propanamine (72.1 g, 447 mmol) over a period of 45 minutes. It was then refluxed for one hour. The reaction mixture was cooled in an ice bath and while stirring vigorously, aqueous sodium hydroxide (20%, 120 ml) was added dropwise. The ether solution was separated, dried over magnesium sulfate and concentrated to dryness yielding 66.1 g of the title compound.

후처리

  1. temperatureIt was then refluxed for one hour
  2. temperatureThe reaction mixture was cooled in an ice bath
  3. customThe ether solution was separated
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-67f93610a6b642f4894926ad22ab25d9
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04749792

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