HCID 20136772, 화합물 → 2-amino-5-isopropylbenzotrifluoride

HRID 579856노트

반응식

HRID 579856 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]=1[C:13]([F:14])([F:15])[F:16]

참가 물질

4

반응물 1

HCID 20136772HCID 20136772, 화합물

생성물 1

HCID 27752232-amino-5-isopropylbenzotrifluoride수율 97.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

330 g of 2-nitro-5-isopropylbenzotrifluoride in 1,200 ml of methanol are initially introduced into a hydrogenation apparatus, and 30 g of Raney nickel are added. After the system has been flushed with hydrogen, a hydrogenation is carried out at 25°-45° C. under a pressure of 30 bar of hydrogen. After the hydrogen absorption is complete, the solution is filtered to separate off the catalyst. After the solvent has been distilled off, the product is distilled. 280 g of 2-amino-5-isopropylbenzotrifluoride (boiling point: 95°-8° C./18 mbar, nD20 : 1.4810) are obtained.

후처리

  1. additionare added
  2. customAfter the system has been flushed with hydrogen
  3. customis carried out at 25°-45° C. under a pressure of 30 bar of hydrogen
  4. customAfter the hydrogen absorption
  5. filtrationthe solution is filtered
  6. customto separate off the catalyst
  7. distillationAfter the solvent has been distilled off
  8. distillationthe product is distilled

출처 및 근거

ORD 기록
ord-dfd5552c4a3344a79a6874cd30b81d7c
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04749813

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