Hydrochloric Acid → 1-(Imidazo[1,2-a]pyridin-6-yl)propan-2-one

HRID 579966

반응식

HRID 579966 반응식
[N+]([C:4]([CH3:15])=[CH:5][C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH:12]=[CH:13][N:14]=2)[CH:11]=1)([O-])=O.Cl.[OH2:17]>CCO>[N:14]1[CH:13]=[CH:12][N:10]2[CH:11]=[C:6]([CH2:5][C:4](=[O:17])[CH3:15])[CH:7]=[CH:8][C:9]=12

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 539155686-(2-Nitro-1-propenyl)imidazo[1,2-a]pyridine

생성물 1

HCID 138523111-(Imidazo[1,2-a]pyridin-6-yl)propan-2-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

In 25 ml of water and 25 ml of EtOH, 1.14 g of 6-(2-nitro-1-propenyl)imidazo[1,2-a]pyridine was heated to 80° C. together with 100 mg of ferrous chloride. With stirring, 2.5 ml of conc. hydrochloric acid was added at a refluxing rate and the mixture was stirred of 1 hour. Upon heating, insoluble matter was removed by filtration. After the insoluble matter was thoroughly washed with ethanol, the solvent was removed by distillation under reduced pressure. An aqueous sodium bicarbonate solution was added to the residue and the mixture was extracted with chloroform. After washing with water and drying over magnesium sulfate, chloroform was removed by distillation under reduced pressure. The residue was purified by column chromatography to obtain 500 mg of 1-(imidazo[1,2-a]pyridin-6-yl)-2-propanone.

후처리

  1. stirringthe mixture was stirred of 1 hour
  2. temperatureUpon heating
  3. custominsoluble matter was removed by filtration
  4. washAfter the insoluble matter was thoroughly washed with ethanol
  5. customthe solvent was removed by distillation under reduced pressure
  6. additionAn aqueous sodium bicarbonate solution was added to the residue
  7. extractionthe mixture was extracted with chloroform
  8. washAfter washing with water
  9. dry with materialdrying over magnesium sulfate, chloroform
  10. customwas removed by distillation under reduced pressure
  11. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-322725c5bea54e23b380427b1df4f5b1
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04751227

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