Acetic Acid → N-Acetyl-2,6-xylidine

HRID 579968

반응식

HRID 579968 반응식
[NH2:1][C:2]1[C:3]([CH3:9])=[CH:4][CH:5]=[CH:6][C:7]=1[CH3:8].[C:10](OC(=O)C)(=[O:12])[CH3:11].C(O)(=O)C>O>[C:10]([NH:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9])(=[O:12])[CH3:11]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 68962,6-DimethylanilineHCID 7918Acetic Anhydride

생성물 1

HCID 16616N-Acetyl-2,6-xylidine수율 92.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 25 ml of 2,6-xylidine (0.20 mole) was added slowly a mixture of 25 ml of acetic anhydride (0.26 mole) and 25 ml of acetic acid (0.44 mole) under stirring at room temperature. The mixture was stirred for 30 minutes at room temperature and, then, diluted with water. The crystalline precipitate was collected by filtration to give 30.1 g (91%) of the title compound (m.p. 182°-184° C.; colorless needles).

후처리

  1. stirringThe mixture was stirred for 30 minutes at room temperature
  2. filtrationThe crystalline precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-65932ea602734fb29d525f9b6ee3ee14
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04751232

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