Diethyl Ether → 2-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione

HRID 580118노트

반응식

HRID 580118 반응식
O1CCOCC1.[NH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][N:9]=1.[C:17]1(=O)[O:22][C:20](=[O:21])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.C(OCC)C>O>[C:17]1(=[O:22])[N:7]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][N:9]=2)[C:20](=[O:21])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 6811Phthalic AnhydrideHCID 133991H-indazol-3-amineHCID 312751,4-Dioxane

생성물 1

HCID 27558572-(1H-Indazol-3-yl)-1H-isoindole-1,3(2H)-dione수율 87%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To 50 ml of dioxane were added 5.0 g of 3-aminoindazole thus obtained and 6.68 g of phthalic anhydride, and the mixture was stirred for 5 hours at 120° C. After the mixture was condensed under reduced pressure, the condensed residue was added with 30 ml of diethyl ether and stirred under cooling with ice and water for 30 minutes to separate crystals. Then the crystals were obtained by filtration and dried under reduced pressure to give 8.6 g of 3-phthalimidoindazole having the following analytical values in a yield of 87%.

후처리

  1. customthus obtained
  2. customcondensed under reduced pressure
  3. customto separate crystals
  4. customThen the crystals were obtained by filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-329e63e25bce4dd8a5bb5671c824753d
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04751302

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