Chlorine → 1-(2-Fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethyl-4-chloropyrazole

HRID 580266노트

반응식

HRID 580266 반응식
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])=[CH:4][C:3]=1[N:14]1[C:18]([CH3:19])=[CH:17][C:16]([CH3:20])=[N:15]1.[Cl:21]Cl>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([O:9][S:10]([CH3:13])(=[O:12])=[O:11])=[CH:4][C:3]=1[N:14]1[C:18]([CH3:19])=[C:17]([Cl:21])[C:16]([CH3:20])=[N:15]1

참가 물질

4

반응물 2

HCID 24526ChlorineHCID 137982511-(2-Fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethylpyrazole

생성물 1

HCID 137983221-(2-Fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethyl-4-chloropyrazole수율 99.6%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Into a solution of 1-(2-fluoro-4-chloro-5-methylsulfonyloxyphenyl)-3,5-dimethylpyrazole (31.9 g) in chloroform (200 ml) was introduced chlorine gas (7.1 g) for 10 minutes under water-cooling, and then the reaction mixture was stirred for further 30 minutes to effect the chlorination reaction. Removal of the solvent from the reaction solution by distillation in vacuo gave the titled compound (35.2 g) as a pale brown oil. Purification of this oil by silica gel column chromatography yielded a colorless oil. nD23 =1.5431.

후처리

  1. temperaturecooling
  2. customthe chlorination reaction
  3. customRemoval of the solvent from the reaction solution
  4. distillationby distillation in vacuo

출처 및 근거

ORD 기록
ord-094d6ea7a4884f658cd8493920541ee8
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04752326

반응 노트

불러오는 중…