Water → Sodium oleanolate

HRID 580310노트

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HRID 580310 반응식
[OH-].[Na+:2].[CH3:3][C@@:4]12[C@H:13]3[CH2:14][CH:15]=[C:16]4[C@@H:21]5[CH2:22][C:23]([CH3:27])([CH3:26])[CH2:24][CH2:25][C@:20]5([C:28]([OH:30])=[O:29])[CH2:19][CH2:18][C@@:17]4([CH3:31])[C@:12]3([CH3:32])[CH2:11][CH2:10][C@H:9]1[C:8]([CH3:34])([CH3:33])[C@@H:7]([OH:35])[CH2:6][CH2:5]2.O.ClCCl>C(OCC)C>[CH3:3][C@@:4]12[C@H:13]3[CH2:14][CH:15]=[C:16]4[C@@H:21]5[CH2:22][C:23]([CH3:26])([CH3:27])[CH2:24][CH2:25][C@:20]5([C:28]([O-:30])=[O:29])[CH2:19][CH2:18][C@@:17]4([CH3:31])[C@:12]3([CH3:32])[CH2:11][CH2:10][C@H:9]1[C:8]([CH3:34])([CH3:33])[C@@H:7]([OH:35])[CH2:6][CH2:5]2.[Na+:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6344DichloromethaneHCID 10494Oleanolic Acid3회HCID 14798Sodium Hydroxide4회

생성물 1

HCID 49857633Sodium oleanolate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A 10% aqueous solution of sodium hydroxide is added to an almost saturated solution of oleanolic acid in a water immiscible solvent, for example dichloromethane or diethyl ether. The volume of the sodium hydroxide solution is controlled by the amount of oleanolic acid taken; the final mixture should contain at least one, preferably 1,5 to 3, mole sodium hydroxide per mole oleanolic acid--a large excess of the sodium hydroxide solution may lower the yield. The mixture is mixed well (vigorous stirring or shaking) and the precipitated sodium oleanolate is separated. The sodium oleanolate can be recrystallised from aqueous organic solvents, preferably aqueous methanol or aqueous ethanol.

후처리

  1. additionThe mixture is mixed well
  2. customthe precipitated sodium oleanolate is separated
  3. customThe sodium oleanolate can be recrystallised from aqueous organic solvents, preferably aqueous methanol or aqueous ethanol

출처 및 근거

ORD 기록
ord-72e40d7f526c429e96875cde66ff49b2
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04752606

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