Hydrochloric Acid → HCID 20135070, 화합물

HRID 580407노트

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HRID 580407 반응식
[CH2:1]([C:4]([CH:13]([C:26]1[CH:31]=[CH:30][C:29](OC)=[CH:28][CH:27]=1)[CH2:14][C:15]1[C:20]([C:21]([F:24])([F:23])[F:22])=[CH:19][CH:18]=[CH:17][C:16]=1[NH2:25])([C:9]([O:11][CH3:12])=[O:10])[C:5]([O:7]C)=O)[CH:2]=[CH2:3].C[O-].[Na+].CN(C)[CH:39]=[O:40].Cl>CO>[CH3:12][O:11][C:9]([C:4]1([CH2:1][CH:2]=[CH2:3])[CH:13]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[O:40][CH3:39])[CH2:14][C:15]2[C:20]([C:21]([F:23])([F:24])[F:22])=[CH:19][CH:18]=[CH:17][C:16]=2[NH:25][C:5]1=[O:7])=[O:10]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 10942334Sodium MethoxideHCID 15128673alpha-(2-Propenyl)-[2-(2-amino-6-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester

생성물 1

HCID 20135070HCID 20135070, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

α-(2-Propenyl)-[2-(2-amino-6-trifluoromethylphenyl)-1-(4-methoxyphenyl)ethyl]propanedioic acid, dimethyl ester (9.03 g; 19.4 mmole) and a 25% (by weight) sodium methoxide in methanol solution (20.5 ml; 89.5 mmole; d=0.945; 4.6 eq.) in methanol (100 ml) and dry dimethylformamide (100 ml) were refluxed (~95° C. for four hours. 1N Hydrochloric acid was added with stirring, producing a precipitate that was collected by suction-filtration, washed with water (three times) and dried in vacuo giving ~10 g of the title compound as a solid. The "crude" material was used "as is".

후처리

  1. customproducing a precipitate that
  2. filtrationwas collected by suction-filtration
  3. washwashed with water (three times)
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-80fbf5cdb00a4a1c85d207ae411bf727
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04752645

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