Pyridine → N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide

HRID 580478

반응식

HRID 580478 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([O:12][CH3:13])=[CH:7][CH:8]=2)[N:3]=1.[C:14]([O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21](Cl)=[O:22])(=[O:16])[CH3:15].N1C=CC=CC=1>O>[CH3:13][O:12][C:6]1[N:5]=[C:4]2[C:9]([CH:10]=[CH:11][C:2]([NH:1][C:21](=[O:22])[C:20]3[CH:24]=[CH:25][CH:26]=[C:18]([O:17][C:14](=[O:16])[CH3:15])[CH:19]=3)=[N:3]2)=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 129985583-(Chlorocarbonyl)phenyl acetateHCID 217930277-methoxy-1,8-Naphthyridin-2-amine

생성물 1

HCID 13983395N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide수율 78.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The procedure is similar to that described in Example 3, but starting with 2-amino-7-methoxynaphthyridine (3.5 g), 3-acetoxybenzoyl chloride (4.4 g) and anhydrous pyridine (40 cc). The reaction mixture is poured into water (400 cc) and the precipitate obtained is separated by filtration and then washed with water (6×100 cc) and dried in the air. On recrystallization from ethanol (140 cc) of the product thereby obtained, N-(7-methoxy-1,8-naphthyridin2-yl)-3-acetoxybenzamide (5.3 g), m.p. 172° C., is obtained.

후처리

  1. customthe precipitate obtained
  2. customis separated by filtration
  3. washwashed with water (6×100 cc)
  4. customdried in the air
  5. customOn recrystallization from ethanol (140 cc) of the product
  6. customthereby obtained

출처 및 근거

ORD 기록
ord-2e02604d1e1447bfb7a6e3d9f54c6d2c
출처 데이터셋
uspto-grants-1988_06
특허 번호
US04753941

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