7-Chloro-1,8-naphthyridin-2-amine → N-(7-Chloro-1,8-naphthyridin-2-yl)-4-thiazolecarboxamide
반응식
[S:1]1[CH:5]=[C:4]([C:6]([OH:8])=O)[N:3]=[CH:2]1.[NH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[N:13][C:14]([Cl:20])=[CH:15][CH:16]=2)[N:11]=1>O>[Cl:20][C:14]1[N:13]=[C:12]2[C:17]([CH:18]=[CH:19][C:10]([NH:9][C:6]([C:4]3[N:3]=[CH:2][S:1][CH:5]=3)=[O:8])=[N:11]2)=[CH:16][CH:15]=1참가 물질
4
실험 절차
The procedure is similar to that described in Example 2, but starting with 4-thiazolecarboxylic acid (4.8 g), N,N'-carbonyldiimidazole (7.5 g) and 2-amino-7-chloro-1,8-naphthyridine (4.8 g). The product obtained by precipitation in water is purified by recrystallization in dimethylformamide (350 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-4-thiazolecarboxamide (6 g), m.p. 325° C., is thereby obtained.
후처리
- customis purified by recrystallization in dimethylformamide (350 cc)
출처 및 근거
- ORD 기록
- ord-f0e5d4ae00d04eab8b097595cd343e10
- 출처 데이터셋
- uspto-grants-1988_06
- 특허 번호
- US04753941
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