1-Methylpiperazine → 1-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine

HRID 58049

반응식

HRID 58049 반응식
[Br:1][C:2]1[C:3]([CH3:9])=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[CH3:10][N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:14]2[CH2:15][CH2:16][N:11]([CH3:10])[CH2:12][CH2:13]2)=[N:4][C:3]=1[CH3:9]

참가 물질

4

반응물 2

HCID 531671-MethylpiperazineHCID 148666743-Bromo-6-chloro-2-methylpyridine

생성물 1

HCID 754875401-(5-Bromo-6-methylpyridin-2-yl)-4-methylpiperazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 3-bromo-6-chloro-2-methylpyridine (700 mg, 3.39 mmol) and 1-methylpiperazine (0.753 mL, 6.78 mmol) in DMF (4 mL) was heated in microwave reactor at 150° C. for 50 minutes. The mixture was subsequently purified via preparative HPLC, eluting with a gradient of 10-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA) to give the title compound.

후처리

  1. customThe mixture was subsequently purified via preparative HPLC
  2. washeluting with a gradient of 10-70% ACN (containing 0.035% TFA) in H2O (containing 0.05% TFA)

출처 및 근거

ORD 기록
ord-06e1793c54df47aa974c0aa09112478d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434743B2

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