Hydrochloric Acid → Barbituric Acid
반응식
N1C=CC=C1.[K].ICCCC.[NH:12]1[C:20](=[O:21])[C:18](=O)[C:16](=[O:17])[NH:15][C:13]1=[O:14].Cl>C(O)C.O1CCCC1>[NH:12]1[C:20](=[O:21])[CH2:18][C:16](=[O:17])[NH:15][C:13]1=[O:14]참가 물질
7
실험 절차
Potassium pyrrole (3.0 g., 0.03 mole), 1-iodobutane (9.2 g., 0.05 moles) and 10 ml. of tetrahydrofuran were combined and refluxed for 1.5 hours by which time the reaction mixture had become a thick mass. The reaction mixture was diluted with 30 ml. of water and extracted with 35 ml. of ether. The ether was backwashed with water, then added to a solution of anhydrous alloxan (4.8 g., 0.03 mole) obtained by heating in 50 ml. of ethanol. The ether was distilled away, 6N hydrochloric acid (5 ml., 0.03 mole) was added, and the mixture refluxed for 3 minutes, cooled, evaporated to a gum, and triturated with water to afford title product [5.1 g.; m.p. 135 (dec); m/e 265].
후처리
- temperaturerefluxed for 1.5 hours by which time the reaction mixture
- additionThe reaction mixture was diluted with 30 ml
- extractionof water and extracted with 35 ml
- customobtained
- temperatureby heating in 50 ml
- distillationThe ether was distilled away
- temperaturethe mixture refluxed for 3 minutes
- temperaturecooled
- customevaporated to a gum
- customtriturated with water
출처 및 근거
- ORD 기록
- ord-fd3679523c564aca9f8f87d8fbc6713d
- 출처 데이터셋
- uspto-grants-1988_06
- 특허 번호
- US04753956
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